TLDR
- Akero stock pops 19% as Novo Nordisk rolls out $5.2B MASH drug acquisition.
- Novo Nordisk targets MASH leadership with $5.2B Akero Therapeutics takeover.
- Akero Therapeutics jumps on news of $5.2B buyout deal with Novo Nordisk.
- Novo Nordisk bets big on liver disease, buys Akero in $5.2B cash deal.
- Akero’s MASH breakthrough draws Novo Nordisk’s $5.2B acquisition offer.
AKRO stock jumped 19% pre-market after Novo Nordisk revealed a $5.2 billion acquisition agreement. The surge followed a 1.07% rise in Akero Therapeutics stock to $46.49 at the previous close.

Akero Therapeutics, Inc. (AKRO)
The deal immediately boosted confidence in Akero Therapeutics as markets reacted to the significant premium offered by Novo Nordisk.
The agreement values Akero Therapeutics at $54 per share in cash, along with a potential contingent payment of $6 per share. This structure highlights strong optimism surrounding the future of efruxifermin, Akero Therapeutics’ lead candidate for MASH. The acquisition marks one of the largest buyouts in the metabolic disease sector this year.
Akero Therapeutics’ market performance reflected the strategic appeal of its pipeline and the growing global focus on metabolic health. The pre-market gain underscored investor enthusiasm for Novo Nordisk’s continued expansion into liver and metabolic disease treatments. The transaction reinforced Akero Therapeutics’ position as a key innovator in the biotechnology landscape.
Terms and Structure of the $5.2 Billion Agreement
Akero Therapeutics shareholders will receive $54 per share in cash at closing. Each shareholder will obtain a contingent value right of $6 per share upon regulatory approval of efruxifermin by June 2031. This total consideration values Akero Therapeutics at up to $5.2 billion.
The upfront cash portion represents an equity value of approximately $4.7 billion. It offers a 19% premium to the company’s 30-day volume weighted average price and a 42% premium to its May 19 closing value. Combined with the CVR, Akero Therapeutics shareholders could gain up to a 57% premium if the milestone is achieved.
This acquisition strengthens Novo Nordisk’s leadership in metabolic disease therapeutics. It aligns with its strategy to diversify beyond diabetes into broader cardio-metabolic areas. The collaboration will also accelerate Akero Therapeutics’ development timeline for its late-stage MASH therapy.
Strategic Impact and Industry Context
Efruxifermin remains central to Akero Therapeutics’ growth strategy and scientific vision. It is designed to treat metabolic dysfunction-associated steatohepatitis, a disease with rising prevalence and limited treatments. Novo Nordisk’s expertise in GLP-1 based therapies is expected to enhance the drug’s global reach.
Akero Therapeutics will integrate into Novo Nordisk’s cardio-metabolic division, leveraging its research and commercial infrastructure. This move is expected to advance the Phase 3 SYNCHRONY program and prepare for a large-scale commercial launch. The acquisition provides Akero Therapeutics with resources to accelerate regulatory filings and expand clinical evaluation.
The transaction received unanimous approval from Akero Therapeutics’ Board of Directors. It remains subject to shareholder and regulatory approval, with closing expected by year-end. Akero Therapeutics’ acquisition by Novo Nordisk signals continued consolidation in the biotech sector, driven by strong demand for breakthrough treatments for metabolic diseases.

